3/8/2024 0 Comments Human design profile 1 3![]() The ICAM-1 Kilifi variant lies in a flexible loop proximal to the DBLβ-interacting region. ![]() These mutations are noted in only a few field isolates and mainly in the African/African American population. Our genomic and structural analysis of single nucleotide polymorphisms (SNPs) in ICAM-1 revealed 9 unique mutations each in its distinct A-type and BC-type PfEMP1 DBLβ-interacting regions. Genetic variation in host ICAM-1 plays a significant role in determining susceptibility to malaria infection via clinical phenotypes such as the ICAM-1 Kilifi variant which has been reported to be associated with susceptibility in populations. ![]() ![]() falciparum erythrocyte membrane protein 1) mediates infected erythrocytes adhesion to various surface vascular receptors, including intercellular adhesion molecule-1 (ICAM-1), associating this interaction with severe malaria in several studies. Plasmodium falciparum is responsible for malaria-related morbidity and mortality. ![]()
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